Study of prevalence of sickle cell disorders in and around Yavatmal district
Sickle cell disease (SCD) is the most common inherited disorder of haemoglobin worldwide, predominantly affecting the tribal peoples of central India. The present study was carried out to find out prevalence of sickle cell disordersin and around Yavatmal district. A total of 67,930 individuals were screened under the sickle cell disease control program held on Jan 2004 to Dec 2017 by SVNGMC Yavatmal. Screenings of samples for the presence of the sickle gene was done by solubility test and confirmation was done by cellulose acetate membrane electrophoresis and HPLC method. Among the total samples were screened, 3120 (4.59%) were found heterozygous (Hb AS) and 1725 (2.53%) were homozygous (Hb SS) for SCD, 450 (0.66%) cases were found with other Hb. The prevalence of SCD was more common in the age group of 0 to 20 years with female predominance. The caste wise distribution of solubility test confirmed samples were SC-51.95%, ST-20.21%, NT -16.2%, OBC-8.8%, SBC-1.84% and Open 1.0%. In conclusion, sickle cell disorders was most prevalent in tribals of Yavatmal district withhighly predominant in backward classes especially in schedule caste (SC).
Copyright (c) 2018 International Journal of Biomedical Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
- An author must submit Copyright form After acceptance of the article.