Study of prevalence of sickle cell disorders in and around Yavatmal district

  • Minal Thakre Department of Pathology, Shri Vasantrao Naik Government Medical College, Yavatmal, Maharashtra
  • Kiran Bharti Department of Pathology, Shri Vasantrao Naik Government Medical College, Yavatmal, Maharashtra 445001
Keywords: Sickle cell disease, Haemoglobin, Prevalence, Electrophoresis, HPLC, Heterozygous

Abstract

Sickle cell disease (SCD) is the most common inherited disorder of haemoglobin worldwide, predominantly affecting the tribal peoples of central India. The present study was carried out to find out prevalence of sickle cell disordersin and around Yavatmal district. A total of 67,930 individuals were screened under the sickle cell disease control program held on Jan 2004 to Dec 2017 by SVNGMC Yavatmal. Screenings of samples for the presence of the sickle gene was done by solubility test and confirmation was done by cellulose acetate membrane electrophoresis and HPLC method. Among the total samples were screened, 3120 (4.59%) were found heterozygous (Hb AS) and 1725 (2.53%) were homozygous (Hb SS) for SCD, 450 (0.66%) cases were found with other Hb. The prevalence of SCD was more common in the age group of 0 to 20 years with female predominance. The caste wise distribution of solubility test confirmed samples were SC-51.95%, ST-20.21%, NT -16.2%, OBC-8.8%, SBC-1.84% and Open 1.0%. In conclusion, sickle cell disorders was most prevalent in tribals of Yavatmal district withhighly predominant in backward classes especially in schedule caste (SC).

Downloads

Download data is not yet available.
Published
2018-08-31
How to Cite
1.
Thakre M, Bharti K. Study of prevalence of sickle cell disorders in and around Yavatmal district. IJBR [Internet]. 31Aug.2018 [cited 18Dec.2018];9(8):300-3. Available from: https://www.ssjournals.com/index.php/ijbr/article/view/4745
Section
Original Research Articles